Intravenous Phosphatidtylcholine (IV PC) for Autism Spectrum Disorders
Phosphatidylcholine (PC) is part of group of compounds called phospholipids. Phospholipids are essential components of cell membranes
PC acts as a supplier of choline, which is required for cell membrane integrity and to facilitate the movement of substances in and out of cells. (nutrients in, toxins out) It is also a component of the neurotransmitter acetylcholine, which is necessary for normal brain functioning. Choline is found in the diet mainly in soy but also in egg yolk, brewer's yeast, wheat germ, fish, peanuts, liver and cauliflower.
We are interested in PC for treating Autism spectrum disorders for the following reasons:
PC is protective to all organs, but has a special affinity to the liver. In many cases of autism, liver function tends to be compromised or overburdened. This is due to genetics and its interface with increased modern environmental exposures.
Studies on PC have found it helpful in neurological conditions such as Parkinson’s and Alzheimers disease. Phosphatidylcholine is found in all nerve and brain tissue and it is of utmost importance to optimize the function of these tissues in Autistic patients.
If there is a deficiency of choline then the biochemical process of methylation will be compromised. Methylation capacity is frequently compromised in children with Autism spectrum disorders due to genetic and environmental factors. Methylation is imperative to immune function, DNA/ cellular repair, energy production, neurological function and detoxification. PC is an excellent source of methyl groups, supplying up to three per PC molecule, thereby optimizing methylation capacity.
Clinical Indications:
The best-documented clinical success with PC to date is its significant amelioration of liver damage. The findings from eight double-blind trials and numerous other clinical reports indicate consistent significant clinical benefit, including improvement of enzymatic and other biochemical indicators, faster functional and structural rebuilding of liver tissue, accelerated restoration of subjects' overall well-being, and improved detoxification and biotransformation following PC treatment.
Dosing:
The most bioavailable means of supplementing PC is by intravenous therapy. With IV PC the molecules are 100% absorbed and assimilated into the tissue of the liver.
Frequently, children with ASD may have gastrointestinal issues and IV therapy is a great way to bypass the gut.
There is no toxic level of PC, therefore, the injection of IVPC is extremely safe when administered by a trained professional.